From The Collaborative International Dictionary of English v.0.48 :
man-made \man-made\ adj.
Not of natural origin; prepared or made by humans;
artificial; of substances, made by chemical reaction rather
than extracted from a natural source; as, man-made fibers;
man-made gems. Opposed to natural.
Syn: semisynthetic, synthetic.
[WordNet 1.5]
From WordNet (r) 3.0 (2006) :
man-made
adj 1: not of natural origin; prepared or made artificially;
"man-made fibers"; "synthetic leather" [syn: man-made,
semisynthetic, synthetic]