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2 definitions found
 for loosen up
From WordNet (r) 3.0 (2006) :

  loosen up
      v 1: cause to become unblocked; "The medicine unstuffed my nose
           in minutes!" [syn: unstuff, loosen up] [ant: block,
           choke up, lug, stuff]
      2: become less tense, less formal, or less restrained, and
         assume a friendlier manner; "our new colleague relaxed when
         he saw that we were a friendly group" [syn: relax, loosen
      3: make one's body limber or suppler by stretching, as if to
         prepare for strenuous physical activity [syn: limber up,
         warm up, loosen up]
      4: become less tense, rest, or take one's ease; "He relaxed in
         the hot tub"; "Let's all relax after a hard day's work" [syn:
         relax, loosen up, unbend, unwind, decompress, slow
         down] [ant: tense, tense up]
      5: cause to feel relaxed; "A hot bath always relaxes me" [syn:
         relax, unstrain, unlax, loosen up, unwind, make
         relaxed] [ant: strain, tense, tense up]

From Moby Thesaurus II by Grady Ward, 1.0 :

  33 Moby Thesaurus words for "loosen up":
     amuse, beguile, beguile the time, convulse, delight, divert,
     drown care, ease off, enliven, entertain, exhilarate, fracture one,
     have a ball, have fun, kill, kill time, knock dead, laugh it up,
     live it up, raise a laugh, raise a smile, recreate, refresh,
     regale, relax, slay, solace, tickle, titillate, unbend, unlax,
     unwind, wow

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